John Y L Chiang Selected Research

Cholesterol 7-alpha-Hydroxylase (Cholesterol 7 alpha Hydroxylase)

8/2010	Transgenic expression of cholesterol 7alpha-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice.
11/2007	A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7alpha-hydroxylase gene.

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John Y L Chiang Research Topics

Disease

22	Obesity 01/2022 - 10/2005
11	Non-alcoholic Fatty Liver Disease 01/2022 - 02/2013
11	Liver Diseases (Liver Disease) 06/2020 - 08/2002
11	Fatty Liver 01/2020 - 09/2008
11	Inflammation (Inflammations) 01/2019 - 11/2007
10	Dyslipidemias (Dyslipidemia) 01/2020 - 10/2005
8	Metabolic Diseases (Metabolic Disease) 01/2022 - 02/2009
8	Insulin Resistance 11/2019 - 08/2010
7	Cholestasis 01/2018 - 01/2005
4	Hepatocellular Carcinoma (Hepatoma) 06/2020 - 03/2004
4	Cardiovascular Diseases (Cardiovascular Disease) 01/2020 - 03/2003
4	Metabolic Syndrome (Dysmetabolic Syndrome X) 11/2015 - 01/2009
3	Fibrosis (Cirrhosis) 06/2020 - 09/2009
3	Dysbiosis 01/2019 - 01/2017
3	Liver Cirrhosis (Hepatic Cirrhosis) 01/2019 - 09/2008
2	Alcoholic Fatty Liver 06/2020 - 04/2020
2	Alcoholic Liver Diseases (Alcoholic Liver Disease) 04/2020 - 07/2013
2	Hyperglycemia 01/2020 - 01/2012
2	Body Weight (Weight, Body) 01/2018 - 01/2013
1	Atherosclerosis 01/2020
1	Connective Tissue Diseases (Connective Tissue Disease) 01/2019
1	Type 2 Diabetes Mellitus (MODY) 03/2015
1	Necrosis 03/2014
1	Gallstones (Gallstone) 12/2013
1	Weight Gain 01/2013
1	Ataxia Telangiectasia (Louis Bar Syndrome) 10/2012
1	Hypercholesterolemia 03/2011
1	Hyperlipidemias (Hyperlipidemia) 09/2009
1	Intrahepatic Cholestasis 12/2007

Drug/Important Bio-Agent (IBA)

42	Bile Acids and Salts (Bile Acids)IBA 01/2022 - 08/2002
12	Glucose (Dextrose)FDA LinkGeneric 06/2020 - 01/2009
9	LipidsIBA 06/2020 - 10/2005
9	CholesterolIBA 01/2020 - 08/2002
6	Insulin (Novolin)FDA Link 06/2017 - 09/2006
6	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2017 - 08/2002
5	Pharmaceutical PreparationsIBA 10/2014 - 01/2005
3	Cholic AcidIBA 11/2019 - 12/2013
3	GTP-Binding Proteins (G-Protein)IBA 10/2018 - 10/2014
3	EnzymesIBA 01/2018 - 05/2006
3	Triglycerides (Triacylglycerol)IBA 01/2018 - 08/2002
3	Proteins (Proteins, Gene)FDA Link 10/2013 - 03/2009
2	Lipoproteins (Lipoprotein)IBA 01/2020 - 01/2009
2	SterolsIBA 11/2019 - 12/2013
2	CeramidesIBA 11/2019 - 01/2015
2	Steroid 12-alpha-Hydroxylase (CYP8B1)IBA 11/2019 - 12/2013
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2019 - 10/2018
2	SteroidsIBA 01/2019 - 01/2013
2	Pregnane X ReceptorIBA 10/2014 - 05/2006
2	Fatty Acids (Saturated Fatty Acids)IBA 10/2013 - 01/2009
2	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 03/2011 - 05/2006
2	Cholesterol 7-alpha-Hydroxylase (Cholesterol 7 alpha Hydroxylase)IBA 08/2010 - 11/2007
2	Transforming Growth Factor beta (TGF-beta)IBA 09/2009 - 09/2008
2	CytokinesIBA 11/2007 - 04/2005
1	SodiumIBA 04/2020
1	bile acid binding proteinsIBA 04/2020
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 04/2020
1	FatsIBA 01/2020
1	lipoprotein cholesterolIBA 01/2020
1	Dietary CholesterolIBA 01/2020
1	Mechanistic Target of Rapamycin Complex 1IBA 11/2019
1	fibroblast growth factor 21IBA 11/2019
1	Sterol Regulatory Element Binding Protein 1IBA 11/2019
1	RNA (Ribonucleic Acid)IBA 01/2019
1	Glucagon-Like Peptide 1 (GLP 1)IBA 10/2018
1	Ethanol (Ethyl Alcohol)IBA 01/2018
1	Long Noncoding RNAIBA 10/2017
1	LigandsIBA 03/2015
1	IncretinsIBA 03/2015
1	SphingomyelinsIBA 01/2015
1	Phospholipids (Phosphatides)FDA LinkGeneric 01/2015
1	Calcitriol Receptors (Calcitriol Receptor)IBA 10/2014
1	Constitutive Androstane ReceptorIBA 10/2014
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 05/2014
1	Taurocholic Acid (Sodium Taurocholate)IBA 03/2014
1	Taurodeoxycholic AcidIBA 03/2014
1	Nonesterified Fatty Acids (NEFA)IBA 10/2013
1	Cytochrome P-450 CYP2E1 (CYP2E1)IBA 07/2013
1	EndocannabinoidsIBA 07/2013
1	Reactive Oxygen Species (Oxygen Radicals)IBA 07/2013
1	Estrogen ReceptorsIBA 01/2013
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 10/2012
1	AMP-Activated Protein KinasesIBA 10/2012
1	Streptozocin (Streptozotocin)FDA Link 01/2012
1	Histones (Histone)IBA 01/2012
1	CannabinoidsIBA 08/2011
1	Choline (Choline Chloride)IBA 09/2009
1	Plasminogen InactivatorsIBA 09/2009
1	Plasminogen Activator Inhibitor 1IBA 09/2009
1	Messenger RNA (mRNA)IBA 09/2009
1	Fenofibrate (CiL)FDA LinkGeneric 09/2009
1	Methionine (L-Methionine)FDA Link 09/2009
1	PPAR alphaIBA 09/2009
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2009
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2008
1	Transforming Growth Factor beta1 (TGF beta 1)IBA 11/2007
1	Cytochrome P-450 CYP3AIBA 05/2006
1	Rifampin (Rifampicin)FDA LinkGeneric 01/2005

Therapy/Procedure

7	Therapeutics 04/2020 - 10/2005
5	Drug Therapy (Chemotherapy) 01/2022 - 08/2002
1	Bariatric Surgery 03/2015